Magic mushrooms 'reboot' brain in depressed people – Imperial College London researchers used psilocybin to treat a small number of patients with depression. Images of patients’ brains revealed changes in brain activity that were associated with marked and lasting reductions in depressive symptoms.



View original post [theguardian.com]




Comments:

13 Oct 2017 20:39 - +6436
You walk into the doctors and tell them you have depression. Doctor hands you some magic mushrooms and asks, "Have you tried turning it off and on again?"
13 Oct 2017 21:59 - +1885
I suffered the loss of my brother when I was 13. I shut myself in my head, built a solid mental castle and was pretty much a living zombie. Barely talked, never did anything, emotionless for years. Didn't know it as depression for the first few years, but around 18 my mental foundations were cracking and it was hard to keep years of emotions shut inside. I was an unstable mess. Therapy and antidepressants weren't helping me. I started smoking weed heavily because it burnt me out where Id just be. Too stoned to think or worry. Eventually around 19 I got a hold of some shrooms with some friends. That trip changed my life. It allowed me to really slow down my thoughts and go through each one meticulously. Without feeling grief or anger. Just really pick the last 6 years of my life apart, in a good way. It let me come to terms with events that had happened, and made it clear in my mind what I needed to do to start truly enjoying my life, and get back to being the person I was before my brothers death and depression brought me down. It was an immediate change. The next day I woke up and just felt new. Lighter, brighter. A large weight off my shoulders. Cliche, but true. I probably wouldn't be here today, almost ten years later, if not for that first trip. Thanks shrooms. I enjoy my life now.
13 Oct 2017 21:12 - +1733
I remember doing shrooms in high school. It made me extremely sad the entire time thinking what a bitch I was, reliving shitty things I have done or said and I just kept thinking that I needed to treat others better. Once sober I did just that and it’s been something that has stuck with me since. Gained a lot more friends, better relationships with family- the whole nine. So yeah- it sucked during the time but had a long lasting positive effect on me.
13 Oct 2017 20:47 - +253
It works, it also was very effective treating ptsd when the us military studied it a few decades ago. It has a power of giving the subject a introspective look at why they are unhappy or sad. It is one of the only drugs where the person actually feels better after it's worn off. Their is a reason why it's been used by shamans for thousands upon thousands of yrs. the trappings may change but the wants needs and feelings are always there.
13 Oct 2017 21:53 - +218
Tried it only once, wasn't depressed at the time, but the word "reset" here hits the bullseye. My trip consisted of reliving childhood memories I haven't remembered in years, appreciating my position in life, my close friends, my family. I cried tears of joy for a large portion of it, and was only sad when I noticed I was sobering up. Truly made me rethink my perspective of life, and even death itself. Loved it
13 Oct 2017 22:03 - +179
Every time there's a popular post about shrooms, it's full of comments from people claiming it cured their crippling lifelong depression, and others claiming they use to be normal, but they had a bad trip, and *now* they have crippling depression. As someone who's done mushrooms numerous times, I still have no idea which to believe. edit: I a word
13 Oct 2017 19:11 - +163
Journal reference: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran & David J Nutt Scientific Reports 7, Article number: 13187 (2017) doi:10.1038/s41598-017-13282-7 Link: https://www.nature.com/articles/s41598-017-13282-7 Published online: 13 October 2017 Abstract > Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other ‘psychedelics’ yet were related to clinical outcomes. A ‘reset’ therapeutic mechanism is proposed.
13 Oct 2017 21:30 - +144
Man I wish there was something for ADHD that reacted like these drugs do for depression depression. Being able to go take a single dose and go months with out having to take another.
13 Oct 2017 22:22 - +142
I have done over 200 hits of acid and have ate over 70 grams of shrooms over my lifetime. My last Shroom trip I realized I was an alcoholic and drug addict and my life was going nowhere. Also during that trip, I had a conversation with a plastic wwe wrestler and he just kept talking shit to me for the decisions I made and told me I needed to get my shit together. It made me question every decision I ever made and realize i needed to go back to school and get sober to help others who were addicts. About a month after that trip I quit my job, moved out of my house, went back to my home state and checked into rehab. 9 months later I'm still sober and am in my first semester back at school for social work and drug counseling. That shroom trip changed my whole life.
13 Oct 2017 22:10 - +107
pro tip: if your trip is going south or you feel too uncomfortable, you probably just have to use the bathroom and your brain forgot how to tell you
13 Oct 2017 21:06 - +105
They also trap people on top of an RV for 1/2 a day at Bonnaroo 07. I missed "The Police". :(
13 Oct 2017 22:28 - +76
A mushroom once told me that this planet is the mushroom-planet, because there would be no life and no death without mushrooms. He said that mushrooms are neither animals nor plants, but that they connect both realms withanother when plants rot and flesh decays. He said that nothing of all on this planet would exist if it weren't for the mushrooms. You live so that you have to shit and to die. It is all for the mushrooms, because they grow on shit and corpses, he said. The meaning of life is to be livestock for the mushrooms, he said. Reality is but a big shroom-trip floating around somewhere in the universe, he said.
13 Oct 2017 21:22 - +74
Some really interesting results coming out of studies into disociative drugs like ketamine and psychedelics from psilocybin and lsd through to dmt - seem to be getting impressive results in properly addressing a wide range of mental health issues. Great that research into these areas has opened up again.
13 Oct 2017 21:55 - +47
"The medical pioneers of this time period, known colloquially as 'stoners', discovered many treatments for psychological ailments that conventional medicine had issues dealing with. In the words of one practitioner, 'Hey man, eat these and, like... woah, dude.' The practitioner in question was determined to be 'tripping balls' by skeptical authorities, and was imprisoned for several years."
13 Oct 2017 21:57 - +26
Well i took 5 gs once and i saw god then i met satan
13 Oct 2017 22:10 - +22
Yeah, but jeff sessions says only jesus can cure depression
13 Oct 2017 22:06 - +22
It really annoys me that we've made illegal things that DO have medicinal use. But hey, war on drugs is a total success.. amirite?
13 Oct 2017 21:35 - +21
Too bad the article starts by typoing "psychadelics", I don't feel comfortable sharing it with friends now
13 Oct 2017 22:17 - +13
I wonder how many times science has to come to this conclusion before the legal system stops pretending it doesnt notice.
13 Oct 2017 22:12 - +12
In my youth, we called psychedelics 'mental detergent' and took them when we wanted to clean out all the dirt. Maybe we were on to something.
13 Oct 2017 22:00 - +12
Anywhere I can put myself forward to be a test subject? Legit, depression kills me every day.
13 Oct 2017 22:11 - +11
Not only this but it has potential to effectively cure cluster headaches. I suffer from them seasonally and it's literally the worst.. friends started acquiring them a bit too late and I'm done until next Aug-Sept. Supposedly they prevent a cycle or completely interrupt them. If I find a study I'll edit and link it.
13 Oct 2017 21:31 - +10
Not sure if I took real lsd, but ye boii that made me happy. Had quite severe depression on the brink of ending my life. Did not take it because depression, but I later found out that my positive attitude might actually have something to do with it. I feel good and haven't tried any drugs for a year. Anyone have the same experience? Maybe with mdma or mushrooms also? Want to try mushrooms, but they are hard to find in some corners of the world
13 Oct 2017 22:38 - +7
TIL - I wanna try shrooms. I'm 32 years old.. I feel like I missed the boat.
13 Oct 2017 22:14 - +7
I really want to try this for my own depression. But I have no idea how to obtain them and I’d have to try them alone which seems a bit scary.
13 Oct 2017 21:59 - +6
I believe it. I felt like I had a "clean slate" on how I view the world around me after tripping. It gives you this deeper sense of understanding of yourself and the world.
13 Oct 2017 22:56 - +5
I struggled with severe anxiety and depression for most of my life and I’ve had almost every symptom of borderline personality disorder but one day I took around 200ug of LSD and it was truly profound. Since then I’ve had literally none of the symptoms I used to experience on a daily basis. I’m not saying psychedelics are for everyone but they’ve greatly improved the quality of my life
13 Oct 2017 22:11 - +5
I have tried shrooms only once in my life. my life was a mess at the time. the experience I had gave me new direction and the resolve to overcome the challenges I faced.

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